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Both drugs deliver significant, clinically meaningful weight loss and the numbers are strikingly close: Wegovy HD 7.2 mg: ~20.7% average body weight loss at 72 weeks (STEP UP trial) Zepbound 15 mg: ~20.9% average body weight loss at 72 weeks (SURMOUNT-1 trial) While Zepbound edges out by a fraction in the headline data, the difference is not clinically significant
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