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Toxin accumulation ASD children are more vulnerable to toxins entering their blood due to increased gut permeability and reduced detoxification capacity within the gut itself

2.1 Role of PDEs in schizophrenia Among the eleven PDE families, PDE1B and PDE10A have emerged as especially relevant in the context of schizophrenia due to their high expression in striatal and cortical circuits governing dopaminergic neurotransmission (Nishi and Snyder, 2010

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