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Tirzepatide users (Zepbound / Mounjaro) also reported shedding more often than placebo, but again the rates were modest
In a study of people who switched from semaglutide to tirzepatide, the most common side effects were nausea, constipation, and diarrhea
Although GLP-1 RAs have demonstrated efficacy even without structured behavioral support, their broader therapeutic potentialparticularly regarding long-term behavior change, psychological stabilization, and sustained weight lossmay be most effectively realized when embedded within a biopsychosocial framework
Typically, patients who have already been on it previously tend to tolerate side effects better the second time around
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