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Unger RH, Cherrington AD (2012) Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

Adults with a BMI of 30 or higher were eligible for a prescription, as were those with a BMI of 27 or higher who also had at least one weight-related condition, such as high blood pressure, high cholesterol, or heart disease

Mix of morning and evening readings is also useful for capturing variability

Summary: Most patients notice appetite suppression and early blood glucose improvements within 12 weeks of starting GLP-1 therapy, with measurable weight loss typically appearing after 48 weeks and maximum benefits emerging after several months on the maintenance dose