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Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH
Lipid peroxidation is a free radical chain reaction, mediated by lipoxygenases such as arachidonate 15-lipoxygenase, which recognizes the double-bond sites of PUFAs in membrane phospholipids and converts them into lipid hydroperoxides [57, 61]
Short courses of anti-inflammatory medication Short courses of non-steroidal anti-inflammatory medication, when appropriate for the patient, can typically reduce knee pain and swelling
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