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One study suggests that the decrease in vagal signaling seen with HFD feeding is due to upregulation of K+ channels in the nodose ganglia, increasing hyperpolarization of VANs 67 , while other studies have implicated changes in the gut microbiota as a contributor to vagal afferent desensitization during HFD feeding (see the Gut microbiotabrain connection section)

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Allantoin has been reported to reduces granulosa cells apoptosis in cyclophosphamide (CTX)-injured rats by downregulating the Bax/Bcl-2 ratio (Wang et al., 2023c)

This makes the skin appear instantly lighter, smoother, and clear. However, this effect is artificial and temporary