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[4] [5] Clinical Efficacy: While clinical trials suggest differences in weight loss outcomes between these medications, direct head-to-head comparative trials are limited
Furthermore, obesity would lead to ventricular remodeling and dysfunction, which destroy the structure and physiological function of the heart, and eventually lead to heart failure (32)
Some studies show improvements in insulin sensitivity, fat oxidation, and cellular repair (such as autophagy), while others suggest that calorie restriction alone (regardless of when you eat) may produce similar results
Importantly, these benefits appear to occur independently of baseline glycemic control, suggesting that the cardioprotective properties of GLP-1RAs are not solely attributable to improved blood glucose levels
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