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however, the increase was significant only after 4 weeks

This suggests that the GABAergic innervation of the PVN may originate from the LH, which, in turn, receives projections from the AON, as shown in our study with CTB retrograde tracing from the LH

If bleeding is severe (soaking through protection hourly), persistent (more than 14 days continuous), or accompanied by severe pain, contact your provider for evaluation before deciding whether to continue