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Top-line outcomes: STEP 4 maintenance data is particularly relevant for researchers modelling discontinuation effects: participants who stopped Semaglutide regained approximately two-thirds of lost weight within 1 year, while those continuing maintained their loss, supporting the hypothesis that chronic GLP-1R engagement is required for sustained metabolic effects
JAMA 293(3):330339
Lamperti M, Romero CS, Guarracino F, Cammarota G, Vetrugno L, Tufegdzic B et al (2025) Preoperative assessment of adults undergoing elective noncardiac surgery: Updated guidelines from the European Society of Anaesthesiology and Intensive Care
Moderate coffee intake even slightly increases natural GLP-1 levels in your body, helping appetite control and stable blood sugar [1]
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