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Some gerontologists have even proposed melatonin as an anti-aging hormone supplement, given the convergence of its effects on multiple aging hallmarks (oxidative damage, chronic inflammation, impaired sleep/circadian regulation) (Stanciu et al., 2019)

Researchers have found that the diversity and species of bacteria in the kidneys plays a significant role in the formation of kidney stones from oxalate.[ref] Joint pain, eye problems, skin deposition In addition to forming kidney stones, oxalate crystals can sometimes be deposited in the joints, skin, and retina

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Higher concentrations don't necessarily mean faster results and might cause irritation for some people