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SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes
Understanding Wegovy and Zepbound Before getting into details of how to switch from Wegovy to Ozempic, lets explore how these medications work for weight loss, their mechanisms of action and side effects
doi: 10.1016/j.etap.2024.104201 125 ZhangYHuangHLuoCZhangXChenYYueFet al
This pharmacokinetic profile allows for once-weekly dosing, distinguishing it from shorter-acting GLP-1 compounds
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