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Five SD rats died after 10 days of the administration of the ADC containing four monomer PEG chains, and no animals died within 28 days after the administration of the ADC containing 8 or 12 PEG chains
The GST activity in group 1 ranged between 21 and 28 CDNB-GSH/min/mg protein during the period of investigation (i.e., days 130)
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