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Nearly all studies originate from one research group, raising concerns about independent replication

The 200 to 500mcg figures widely used across clinic and community contexts are derived from animal extrapolation and accumulated self-experimentation, not controlled human trials

Phase 3 TRIUMPH topline figures (often cited around the high-20% range at 6880 weeks) are company-reported and, at the time of writing, are not the peer-reviewed Phase 2 dataset cited above

Those with adrenal fatigue can also be very sensitive to stronger detoxification supplements like glutathione, so care must be taken to start low and go slow