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Where PDE5 inhibitors are not a suitable ED treatment due to a medical contraindication your doctor will be able to discuss alternative options
Both 25-hydroxylases (CYP2R1 and CYP27A1) were expressed in the liver, while CYP27A1 expression was seen only in cultured hepatocytes (FL83B mouse hepatocyte cell line)
10.1016/j.cellsig.2023.110689 Summary Keywords clinical transition, dual inhibitors, phosphodiesterase 10A, phosphodiesterase 1B, schizophrenia Citation Rautela J, Gaurav A, Nissapatorn V, Tan CK, Girol AP, Pereira MDL and Lee VS (2026) PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise
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