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The DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial specifically included patients with chronic kidney disease with or without diabetes to receive dapagliflozin and found that these patients experienced a lower risk of ESRD, GFR decline of at least 50%, or death from renal or cardiovascular causes in comparison to placebo [31]

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The study protocol was reviewed and approved by the institutional review board of Johns Hopkins School of Public Health

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