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Arachidonic acid is subsequently oxygenated by cyclooxygenase (COX) to form prostaglandin H2 (PGH2), which is then converted to PGE2-by-PGE2 synthase (PGES)
In pancreatic cancer, the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene reprograms glutamine metabolism by upregulating aspartate transaminase (GOT1) and repressing GLUD1 to increase the NADPH/NADP(+) ratio for stable redox capacity (Son et al., 2013)
J Biol Inorg Chem
Physician's Desk Reference
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