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For the past few years, many studies have explored the role of a new type of RCD-ferroptosis in CCVDs (Gao et al., 2015
Indeed metformin inhibits the mitochondrial oxidative phosphorylation complex I, leading to increased cellular AMP levels and subsequent stimulation of AMPK, an enzyme that plays key roles in the regulation of cellular energy homeostatis
In short, things slow down in some ways, speed up in others, and the gut has to adjust
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