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The most relevant published human clinical trial is Knig et al

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Given the importance of hyperandrogenism-hyperinsulinemia in PCOS, most of the current therapeutic strategies aim at reducing androgen excess by improving insulin sensitivity, mainly via lifestyle changes and/or pharmacological approaches

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The relentless, rolling waves of nausea that hit during dose escalation drive roughly 10-17% of users to abandon treatment entirely, according to data from the STEP clinical trials

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