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Previous studies using high copy number simple extrachromosomal arrays suggested that APX-1 could substitute for LAG-2 and that the intracellular domain of both ligands is dispensable for ligand activity when driven by lag-2 regulatory sequences [2224]

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On the other hand, if theres minimal improvement after a fair trial (e.g., 48 doses over 2 months), guidelines would suggest discontinuing PT-141fda.gov and exploring other options