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Unlike Erysipelatoclostridium , Lactobacillus was significantly and dramatically increased in 5A-1MQ-treated mice switched from WD to LD relative to their vehicle-treated counterparts and the LD control group

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5.2 Clinical trials of interventions targeting endogenous antioxidant defenses Enhancing endogenous antioxidant defenses, particularly the GSH system, is another strategy to combat ferroptosis

57 GSH depletion occurred without a change in GSSG, suggesting efflux of GSH out of the glia, perhaps with additional increased conversion of GSH to GSSG in response to increased hydrogen peroxide formation