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Immature neutrophils, which are in the early stages of differentiation, are primarily located in the bone marrow and can be rapidly mobilized into the peripheral circulation in response to specific stimuli ( hi , CXCR4 low , and CD62L hi are characteristics of mature circulating neutrophils (22), and chemokines (including CXCL8, CXCL1, CXCL2, and CXCL5) can stimulate the release of neutrophils into the circulation and their migration to inflammatory sites via CXCR2 signaling, where they adhere to the endothelium (2326)
They hypothesized that FMRP downregulates mGluRI
