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The FDA approval of the first oral GLP-1 medication for obesity in December 2025 represents a major milestone in weight loss treatment options
These drugs function by mimicking the natural hormone GLP-1, which is released by intestinal L cells in response to food intake
In an early study, Moens et al
Researchers found that metformin could regulate endometrial tolerance by increasing endometrial glucose transporter protein 4 (GLUT4) expression, modulating the expression of related hormone receptors to affect endometrial transformation, modifying autophagy, as well as modulating DNA/histone modifications and micro RNAs (miRNAs) for transcriptional regulation
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