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While no clinical trial has tested this combination, the anti-apoptotic and antioxidant effects of HIF-PHIs provide a strong mechanistic rationale for synergistic use with agents targeting erythrocyte apoptosis pathways (e.g., Bcl-xL upregulation or NIX inhibition)
& Linkermann, A
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Tirzepatide carries a boxed warning regarding thyroid C-cell tumors based on rodent studies, though human relevance remains uncertain
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