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Limited pilot studies in patients with psoriasis have reported improvements in disease severity scores alongside metabolic benefits, though these findings require confirmation in larger trials

Essentiality of the Key Events Overall, the KEs in this AOP demonstrate moderate essentiality

Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X (2017) A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis