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Prepubertal children with obesity have high free IGF-1 levels and accelerated growth despite reduced Pappalysin levels
GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the dual GIP/GLP-1 agonist tirzepatide carry the clinical evidence: STEP for semaglutide ( The New England Journal of Medicine , 2021), SURMOUNT for tirzepatide (NEJM, 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM, 2024)
Bottom Line Diarrhea affects roughly one in five people taking tirzepatide, but it is usually mild, temporary, and manageable
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