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MMP measurements MMP was assessed using the cationic fluorescent dye tetramethylrhodamine methyl ester (TMRM) (Thermo Fisher Scientific, Waltham, MA, USA)

In the SAH mouse model, BRD4 can impede the generation of A1 subtype astrocytes by inducing Pan-Kla and H4K1la, thereby providing protection for neuronal survival [57]

Meanwhile, in RAAS, ACE's conversion of angiotensin I to angiotensin II, which has a potent vasoconstrictor impact, may cause the adrenal cortex to generate more aldosterone, both of which raise blood pressure