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This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)

GIP activation works synergistically with GLP-1 to enhance insulin secretion and may play an independent role in fat metabolism

International immunopharmacology

While these gain- and loss-of-function experiments have helped reveal the myriad of roles of Wnt/-catenin signaling during development of the vestibular organs, it is important to point out that the levels of Wnt signaling also critically regulate morphogenesis as both inhibiting and activating modulators lead to a malformed vestibular system (Stevens et al., 2003)