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Additionally, tirzepatide demonstrates bias at the GLP1R, favoring the synthesis of cAMP over the recruitment of -arrestin [1]
Consider it more of a short-term tool than a long-term solution
A pattern of 12 weeks on, 4-6 weeks break, repeated several times, produces sustainable results without the receptor desensitization that can occur with extremely long continuous use
When I was training folks for the specific goal of hypertrophy, I would put them through kind of a standard, "Let's rest between sets, move the maximum amount of load, let's cover a spectrum of loading zones." I'm sort of with Brad Schoenfeld
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