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Nature 601(7891):118124
Immunostaining and cell counting results showed that the number of surviving SGNs was significantly increased after the pretreatment with ebselen compared with the peroxynitrite-only group, while remarkably less survived SGNs were detected in gpx1 / mice group compared with WT mice after peroxynitrite treatment (Figures 3D,E)
The study authors found that intravenous injection of 42mg to 1260mg of TB4 was safe in healthy adults, with no dose limiting toxicities or serious adverse events reported [26]
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