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Contrave is contraindicated in patients with uncontrolled high blood pressure, a seizure disorder or history of seizures, current use of other bupropion-containing products (such as Wellbutrin), bulimia or anorexia nervosa, chronic opioid use or current use of opioid agonists like methadone or Suboxone, current use of MAO inhibitors, or known allergy to naltrexone, bupropion, or any component of Contrave

Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

Cells, 10 (6), 1343