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By week 3 or 4 of the pattern, nausea and GI symptoms worsen, and patients don't connect it to the timing change

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If your GIP receptors have desensitized alongside your GLP-1 receptors, switching to a pure GLP-1 agonist removes the GIP stimulus entirely, allowing those receptors to recover while you maintain GLP-1 mediated appetite suppression with a different agonist profile