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Polymeric nanoparticles, like those composed of PLGA or chitosan, provide regulated drug release and safeguard against enzymatic degradation, while improving skin penetration due to their adjustable size, surface charge, and hydrophobicity [296]
In vitro assays using BaF-BO3 cells transfected with the hGH receptor confirmed that AOD9604 does not compete for the hGH receptor and does not induce cell proliferation unlike intact hGH establishing that it operates via a novel mechanism distinct from traditional hGH-stimulated pathways
It may also reduce inflammation markers in the gut
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