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To circumvent the need for intracellular bioactivation of AQ or DEAQ by CYPs, the toxic effects of the synthetic chemically reactive metabolites AQ-QI and DEAQ-QI were studied
This makes it an ideal route for peptide delivery
This remains an actively moving area, however: on February 27, 2026, the HHS Secretary publicly announced an intent to move roughly 14 of the 19 Category 2-listed peptides, reportedly including ipamorelin and CJC-1295, back toward Category 1 status, and multiple industry and legal-news outlets reported further FDA action in the following months easing Category 2-related restrictions on this group of peptides
(August 2005)
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