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This GLP-R1 agonist seems to increase oncogenesis in multiple tissues, including the thyroid, bladder, pancreatic, and colorectal [97, 110, 121]
Enhanced Satiety: This drug helps patients feel sated with smaller meals, reducing overall calorie intake
The effects are subtle
Randomization was stratified according to country, sex (female, male) and per cent weight reduction at the end of lead-in ( 90% to demonstrate the superiority of tirzepatide MTD to placebo, for the coprimary endpoints, each at a two-sided significance level of 0.05
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