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Persistently elevated leucine over-activates the mTORC1/S6K1 pathway, leading to IRS-1 serine phosphorylation and impaired insulin signaling (14, 35)

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This may include: Administering intravenous fluids to raise blood pressure Using medications to support heart function Providing oxygen or mechanical ventilation if breathing is compromised Monitoring heart rhythm and neurological status closely In some cases, activated charcoal may be given if the overdose was recent to reduce absorption of the drug

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