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While GLP-1 receptor agonists have a lower risk of hypoglycaemia when used alone (compared to some other diabetes medications), this risk increases significantly when combined with sulfonylureas or insulin

For context, the concentrations required to activate intracellular cascades such as PI3K/Akt, upregulate BDNF, or stimulate autophagy in neuronal tissue are derived from preclinical studies that used substantially higher relative exposures than those achievable in the human brain at therapeutic doses

Licensed clinicians experienced in GLP-1 medication & care Matched to your body, stage and weight loss goal Your dosing adjusts as you progress Q "What happens if something goes wrong?" Your care team

Veldhuijzen van Zanten J, Sandoo A, Metsios GS et al (2019) Comparison of the effects of exercise and anti-TNF treatment on cardiovascular health in rheumatoid arthritis: results from two controlled trials