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To investigate the relative contribution of non-genetic factors that predict GLP1 medication efficacy, we fit a linear model to assess the combined effect of age, sex, pre-treatment BMI, drug type, drug dose and time on drug on total BMI loss (Supplementary Table 3)
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In a recent Mayo Clinic study, postmenopausal women who were overweight or had obesity and combined semaglutide and HRT experienced about 30% more significant weight loss than those using semaglutide alone
This ratio is the primary determinant of the cellular redox state
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