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Short half-life agents (exenatide twice daily or lixisenatide) produce spikes with transient increases in plasma arGLP-1 levels, resulting in intermittent activation of the receptor and have a potent effect on gastric emptying and postprandial glycemia by reducing the rate of glucose entry into the duodenum
They should be having blood draws for comprehensive metabolic profiles beyond just looking at labs for diabetes, he says
GLP-1 receptor agonists enhance glucose-dependent insulin secretion from pancreatic beta cells, meaning they stimulate insulin release only when blood glucose levels are elevated
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