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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy
This has been proven to benefit those with age-related brain diseases like Alzheimers and major depressive symptoms.[ix] And one animal study conducted in New Delhi showed that Acetyl L-Carnitine reduces lipofuscin in the cerebral cortex, hippocampus, striatum and thalamus
However, for those with mild dietary deficiencies and intact absorption mechanisms, high-dose oral tablets can often be sufficient, albeit with potentially slower results
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