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Upon injection, the PLGA matrix undergoes gradual hydrolysis, releasing the peptide over time
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If you take doses too close together, the concentration of the medication in your blood could spike higher than your body is used to
This results in suppression of NF-B signaling and consequent M2-like polarization of tumor-associated macrophages in breast cancer mouse models, highlighting the potential of miR-182 targeting in reprogramming TAMs and limiting breast cancer progression
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