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Yes, fat mass dropped substantially about 10.5 to 10.9 kg in the 8 mg and 12 mg groups
The recommendation: if you need fiber for constipation (common on semaglutide), start with a low dose (half the usual amount) and increase gradually
Assessment and Pathophysiology of Microvascular Disease: Recent Progress and Clinical Implications
Recommendations include: 150-300 minutes weekly moderate-intensity aerobic activity Resistance training 2-3 times weekly to maintain muscle mass Non-exercise activity thermogenesis (NEAT) optimization through increased daily movement Pharmacological Alternatives: Beyond GLP-1 receptor agonists, FDA-approved weight loss medications include: Phentermine-topiramate (Qsymia): Appetite suppressant combination Naltrexone-bupropion (Contrave): Affects reward pathways and appetite Orlistat (Xenical, Alli): Lipase inhibitor reducing fat absorption These alternatives have different mechanisms, adverse effect profiles, and efficacy (typically 5-10% weight loss), allowing individualized selection
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