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At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]
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Safety Profile Sublingual semaglutide is generally well-tolerated, with most side effects being gastrointestinal disturbances such as nausea and diarrhea
What improvements did Novo Nordisk make to GLP-1 therapy
Kim J, Park J, Lim K
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