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The dose increases to 1.2 mg in week two, then 1.8 mg in week three, 2.4 mg in week four, and finally reaches the maintenance dose of 3.0 mg daily from week five onward
The most common side effects were: Nausea Vomiting Diarrhea Constipation Fatigue Abdominal discomfort Early satiety Injection site reactions Increased heart rate in the first 24 weeks, but that returned to normal after 24 weeks
Wu GQ, Jia BY, Li JJ, Fu XW, Zhou GB, Hou YP, Zhu SE
Tirzepatide does not change this requirement it reinforces the need for strict fasted administration to avoid compounding gastric delays
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