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It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood
AOD-9604 works entirely at the fat cell level through beta-3 adrenergic receptor activation
None of the evidence reported in these papers is close to being convincing, and we would need extraordinary data to overcome the lack of plausibility for these patches working in the first place
2021;2:72035.e724
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