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In a 2024 pilot study, older adults with mild B12 deficiency who supplemented for three months saw significant gains in muscle strength and quality, reaching about the same level as people whose B12 was already healthy
As such, the AMYR agonists (combined with other incretin class members) could represent the elusive drug candidate to address the multi-hormonal dysregulations of diabetes subtypes and qualify as a precision medicine approach that surpasses the long overdue division into T1DM and T2DM
McMahon, F
B12 deficiency is more widespread than most people appreciate, and certain groups are at higher risk than others: People following plant-based diets B12 is found almost exclusively in animal products, making vegans and vegetarians particularly vulnerable to deficiency People with digestive absorption issues conditions such as Crohn's disease, coeliac disease, and atrophic gastritis can affect the body's ability to absorb B12 from food Those taking certain medications metformin for diabetes and proton pump inhibitors for acid reflux are among the medications known to reduce B12 absorption over time Older adults the ability to absorb B12 from food decreases with age, making deficiency increasingly common in older populations People under significant stress chronic stress depletes B12 stores more rapidly than normal Those with a consistently poor diet even without a specific condition, a diet low in B12-rich foods can lead to gradually declining levels over time If you fall into one or more of these categories and have been experiencing symptoms that could be consistent with low B12, it's worth having a conversation about whether an injection could help
