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AEDG peptide regulation of the expression of human circadian rhythm genes upon accelerated aging of the pineal gland
These changes in intracellular GSH levels affect key biological processes, including signal transduction, cell survival, proliferation (167) and various forms of cell death (168,169)
(2) the specific CI inhibitor IACS-010759 was recently reported to promote neurotoxicity, making this an unattractive agent for combination therapy in CRC given the neurotoxicity long-recognized with oxaliplatin treatment 51
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