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When to Seek Care from a Healthcare Professional Here are some red-flag signs that you should stop taking glycine supplements or seek medical care: allergic reaction symptoms, like swelling, hives, or having trouble breathing new or worsening mood changes, confusion, severe sleep disruption, or unusual neurologic symptoms persistent GI distress, such as vomiting, severe abdominal pain, or dehydration If youre taking glycine supplements specifically to help with your sleep, dont expect it to work miracles