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In mouse models, the team introduced combined therapy including PD-L1 blocker and cyst(e) inase (a bioengineered enzyme that degrades cystine and cysteine) and such treatment can enhance the efficacy of CTL-mediated anticancer effects, supporting the idea that inducing ferroptosis could be considered a productive way for treating cancer and overcoming immunotherapy resistance (Wang et al., 2019)
In addition, it can also be associated with other medical conditions including epilepsy, congenital cardiac defects, gastrointestinal (GI), immunological, endocrine/metabolic and sleep disorders, as well as psychiatric comorbidities like ADHD and anxiety
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