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While probiotics are generally considered safe for healthy individuals, serious adverse events can occur in specific populations, and certain symptoms warrant immediate medical evaluation

Infections with Granulibacter bethesdensis (a Gram-negative rod bacterium that causes chronic necrotizing lymphadenitis and sepsis) and Burkholderia gladioli (a Gram-negative rod bacterium which can cause osteomyelitis and sepsis) should prompt evaluation for CGD

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39 As shown in the LEADER study (NCT01179048), the secondary composite outcome of persistent doubling of the serum creatinine level, new-onset persistent macroalbuminuria, end-stage renal disease or death due to renal disease occurred significantly less frequently in the treatment group than in the placebo group, with a hazard ratio of 0.78