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Clinical trials on glutathione for skin lightening have included participants with Fitzpatrick types IV and V specifically, showing good results and no adverse effects at topical and oral concentrations

The lower alpha diversitybut not serum LPS levelsalso correlated with increased intestinal permeability, measured by a plasma lactulose/rhamnose ratio 90 min after ingestion of the sugar solution, which is a less validated way to assess intestinal permeability because this one sampling point does not take into account renal clearance

References 1 ElahiS

However, permeability increases measured in most studies are secondary to epithelial damage, which allows non-selective flux via the unrestricted pathway